DNA-hybrid-gated functional mesoporous silica for sensitive DNA methyltransferase SERS detection.
نویسندگان
چکیده
Mesoporous silica nanoparticles (MSNs) were used as a nano-carrier/amplifier to develop a novel MSN-SERS probe for DNA MTase detection. High sensitivity, good selectivity, and rapid analysis are achieved.
منابع مشابه
SERS-based immunoassay of tumor marker VEGF using DNA aptamers and silica-encapsulated hollow gold nanospheres.
A novel SERS-based sandwich immunoassay using DNA aptamers, silica-encapsulated hollow gold nanospheres (SEHGNs) and a gold-patterned microarray was developed for sensitive detection of VEGF (vascular endothelial growth factor) angiogenesis protein markers. Here, a DNA aptamer conjugated to SEHGN was used as a highly reproducible SERS-encoding nanoprobe, and a hybrid microarray including hydrop...
متن کاملOligonucleotide-capped mesoporous silica nanoparticles as DNA-responsive dye delivery systems for genomic DNA detection.
New hybrid oligonucleotide-capped mesoporous silica nanoparticles able to detect genomic DNA were designed.
متن کاملDNA-capped mesoporous silica nanoparticles as an ion-responsive release system to determine the presence of mercury in aqueous solutions.
We have developed DNA-functionalized silica nanoparticles for the rapid, sensitive, and selective detection of mercuric ion (Hg(2+)) in aqueous solution. Two DNA strands were designed to cap the pore of dye-trapped silica nanoparticles. In the presence of ppb level Hg(2+), the two DNA strands are dehybridized to uncap the pore, releasing the dye cargo with detectable enhancements of fluorescenc...
متن کاملLabel-free detection of DNA by combining gated mesoporous silica and catalytic signal amplification of platinum nanoparticles.
This article presents a simple label-free detection of nucleic acids by using Pt@mesoporousSiO2 as a "smart" reporter, whose pores are first capped by single-stranded (ss) probe DNA. The detection signal is then amplified using the TMB oxidation reaction catalysed by Pt NPs while hybridizing with the complementary ss target DNA, which makes the pores of mesoporous SiO2 open through hybridization.
متن کاملHighly Sensitive Fluorescence Probe Based on Functional SBA-15 for Selective Detection of Hg2+
An inorganic-organic hybrid fluorescence chemosensor (DA/SBA-15) was prepared by covalent immobilization of a dansylamide derivative into the channels of mesoporous silica material SBA-15 via (3-aminopropyl)triethoxysilane (APTES) groups. The primary hexagonally ordered mesoporous structure of SBA-15 was preserved after the grafting procedure. Fluorescence characterization shows that the obtain...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 51 73 شماره
صفحات -
تاریخ انتشار 2015